Disseminated Kaposi sarcoma presenting as an endophytic renal mass with concurrent primary effusion lymphoma: A case report.

Shamieh Banihani, Alexandra C Greb, Abhinav R Thummala, Jonathan R Said, Inderpreet S Saini

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In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Shamieh BanihaniDepartment of Internal Medicine, UCLA-Olive View Medical Center, Sylmar, CA, USA.

Alexandra C GrebDepartment of Internal Medicine, University of California, Los Angeles (UCLA) David Geffen School of Medicine, Los Angeles, CA, USA.

Abhinav R ThummalaDepartment of Internal Medicine, University of California, Los Angeles (UCLA) David Geffen School of Medicine, Los Angeles, CA, USA.

Jonathan R SaidDepartment of Pathology, University of California, Los Angeles (UCLA) David Geffen School of Medicine, Los Angeles, CA, USA.

Inderpreet S SainiDepartment of Internal Medicine, University of California, Los Angeles (UCLA) David Geffen School of Medicine, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary effusion lymphoma (PEL) is a rare, aggressive B-cell lymphoma associated with human herpesvirus-8 (HHV-8) and immunodeficiency, notably in untreated human immunodeficiency virus (HIV). Kaposi sarcoma (KS) is also an HHV-8-driven malignancy. Most cases of KS present with cutaneous manifestations, with less frequent visceral involvement. We present the case of a 63-year-old male with untreated HIV/AIDS who developed KS presenting as an endophytic renal mass with lymphovascular invasion and concurrent HHV-8-positive PEL. Biopsies confirmed KS in the kidney and PEL in the pleural fluid. Given profound immunosuppression, he was started on combination antiretroviral therapy and chemotherapy. This case represents a rare presentation of KS and highlights the aggressive course of HHV-8-driven malignancies in the setting of advanced HIV. Delayed antiretroviral initiation likely contributed to disease progression, emphasizing the critical role of early HIV treatment.

Indexed as

Human herpesvirus-8 (HHV-8)Human immunodeficiency virus (HIV)Kaposi SarcomaPrimary effusion lymphoma (PEL)

Identifiers

PMID40688424

DOI10.1016/j.idcr.2025.e02310

PMCPMC12273247

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