Evidence map›Paper›PMID 40688364›Full record

ArticleCommunications materials2025

Evaluation of in situ tissue-engineered arteriovenous grafts suitable for cannulation in a large animal model.

Paul J Besseling, Wojciech Szymczyk, Martin Teraa, Raechel J Toorop, Paul A A Bartels, Boris Arts, Rob C H Driessen, Arturo M Lichauco, Hidde C Bakker, Joost O Fledderus and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Paul J BesselingDepartment of Nephrology and Hypertension, Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.
Wojciech SzymczykDepartment of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0009-0006-1258-5220
Martin TeraaDepartment of Nephrology and Hypertension, Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-6751-6752
Raechel J TooropDepartment of Vascular Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands.
Paul A A BartelsDepartment of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.
Boris ArtsDepartment of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.
Rob C H DriessenDepartment of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0003-3660-9371
Arturo M LichaucoDepartment of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.
Hidde C BakkerDepartment of Nephrology and Hypertension, Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.
Joost O FledderusDepartment of Nephrology and Hypertension, Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.
Gert J de BorstDepartment of Vascular Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands.
Patricia Y W DankersDepartment of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0002-8997-181X
Carlijn V C BoutenDepartment of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.ORCID 0000-0003-1035-5094
Marianne C VerhaarDepartment of Nephrology and Hypertension, Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-3276-6428

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sustainability of vascular access for hemodialysis is limited by frequent interventions and the inability of synthetic grafts to self-heal. Tissue engineering offers a solution through biodegradable grafts that remodel into autologous tissue. Here we assess electrospun polycarbonate-bis urea (PC-BU) vascular scaffolds (6mm-inner-Ø), reinforced with 3D-printed polycaprolactone coils, in a goat model, and compared them to expanded polytetrafluoroethylene (ePTFE) controls. The tissue-engineered grafts were repeatedly cannulated starting two weeks after implantation and were evaluated using computed tomography and histological analyses. By 12 weeks, the PC-BU grafts remodel into autologous tissue while maintaining structural integrity, maintaining integrity without dilations, ruptures, or aneurysms. Cannulation does not interfere with scaffold degradation or neo-tissue formation. Although the patency rate is lower for the PC-BU grafts (50%) compared to ePTFE (100%), the engineered grafts exhibit a self-healing response not seen in ePTFE. These findings demonstrate the potential of PC-BU tissue-engineered grafts as healing, functional vascular access solutions for hemodialysis, supporting cannulation during tissue transformation.

Indexed as

Preclinical researchRegenerationTissue engineering

Identifiers

PMID40688364
PMCPMC12267051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.