Evidence map›Paper›PMID 40688329›Full record

ArticleJournal of thoracic disease2025

Causality of genetically determined gut microbiota on lung cancer: a Mendelian randomization study.

Huiwen Yu, Chongde Pan, Yu Jiang, Yuechun Lin, Fei Chen, Yulin Zhao, Hengrui Liang, Wei Wang, Jianxing He, Xin Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huiwen Yu *Department of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Chongde Pan *Department of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yu Jiang *Department of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yuechun Lin *Department of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Fei ChenDepartment of Clinical Medicine, The First School of Clinical Medicine, Guangzhou Medical University, Guangzhou, China.
Yulin ZhaoDepartment of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Hengrui LiangDepartment of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wei WangDepartment of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jianxing HeDepartment of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xin XuDepartment of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Ying HuangDepartment of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung cancer (LC) is a growing global health concern, characterized by a persistent static 5-year survival rate and a worrisome increase in LC-related deaths. Despite substantial research, the connection between gut microbiota and LC remains a topic of ongoing debate. Conventional observational studies are susceptible to potential confounders and inverse causation. This study aims to investigate the potential causal association between gut microbiota and LC by using Mendelian randomization (MR). Methods: There were 5,717,754 gut microbiota-related single-nucleotide polymorphisms (SNPs) identified from the MiBioGen consortium (18,340 participants from 24 cohorts) used as instrumental variables in our study. Gut microbiota composition was measured using 16S rRNA sequencing, and association estimates for 211 bacterial taxa were obtained after adjusting for age, gender, technical variables, and genetic principal components. Genetic statistics related to LC were obtained from the Integrative Epidemiology Unit (IEU) database, involving 11,348 cases and 15,861 controls. LC cases were diagnosed based on histopathological confirmation, which is the gold standard for LC diagnosis. The inverse variance-weighted method was applied to estimate the causation between gut microbiota composition and LC. Colocalization analysis was also performed within a 500 kb window of identified SNPs, with posterior probability (PP)4/(PP3 + PP4) >0.8 confirming colocalization signals. Results: There were 27,209 eligible studies involving 11,348 patients included. Inverse-variance weighted (IVW) analysis revealed significant associations for one taxonomic order, two families, and seven genera within the gut microbiota composition. Specifically, we observed significant associations with order Bifidobacteriales [odds ratio (OR) =0.81, 95% confidence interval (CI): 0.68-0.97, P=0.03], family Bifidobacteriaceae (OR =0.81, 95% CI: 0.69-0.97, P=0.03), family Peptococcaceae (OR =0.80, 95% CI: 0.67-0.96, P=0.02), genus Conclusions: These findings suggest that targeting gut microbiota-associated pathways, such as short-chain fatty acid (SCFA) production, may offer novel strategies for LC prevention and treatment. Future research should explore the clinical implications of modulating gut microbiota to improve LC outcomes, particularly in high-risk populations.

Indexed as

causal inferencegut microbiotalung cancer (LC)Mendelian randomization (MR)

Identifiers

PMID40688329
PMCPMC12268612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.