ArticleJournal of thoracic disease2025
Protocol for robotic-assisted bronchoscopy versus electromagnetic navigation bronchoscopy for the diagnosis of peripheral pulmonary nodules: a randomized trial (ARTICULAtE study).
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06308120 (A Randomized Controlled Trial to Compare Robotic Assisted Bronchoscopy Ion's Clinical Utility for Peripheral Lung Nodule Access and Diagnosis to ENB), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial to Compare Robotic Assisted Bronchoscopy Ion's Clinical Utility for Peripheral Lung Nodule Access and Diagnosis to ENB
Who cites it
2 citing papers in PubMed.
- Shape-sensing robotic-assisted bronchoscopy (ss-RAB) for peripheral pulmonary nodules: learning curve and diagnostic performance from an initial multicenter experience in China.Respiratory research · 2026Trial
- Advanced Bronchoscopic Approaches to Peripheral Pulmonary Lesions: a Narrative Review of Current and Emerging Techniques.Pulmonary therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Electromagnetic navigation bronchoscopy (ENB) and shape-sensing robotic-assisted bronchoscopy (ssRAB) are the two dominant bronchoscopic technologies for the diagnosis of peripheral pulmonary nodules (PPNs). However, data directly comparing ENB and ssRAB are limited. We designed a randomized controlled trial to compare the diagnostic performance of these two technologies. The primary objective is to evaluate if ssRAB is superior to ENB for the diagnosis of PPNs. Methods: It is a multicenter, open-label, superiority randomized controlled trial. Patients with PPNs suspicious for lung cancer with a long-axis 8 to 30 mm are being approached for enrollment. The first 90 patients are being recruited as lead-in cases to allow the investigators to become familiar with the ssRAB system. A total of 264 patients will be enrolled in the randomized stage. The primary outcome is the diagnostic yield at the 6-month post-procedure follow-up. The secondary outcomes include diagnostic yield using a strict definition, diagnostic sensitivity of malignancies, the incidence of pneumothorax that requires chest tube placement and/or re-hospitalization or extended hospitalization within 1 month post-procedure, and the incidence of intraoperative severe airway bleeding. Enrollment for the study began in 20 March, 2024 and is currently in progress. Discussion: The results of this study will provide evidence to directly compare ssRAB and ENB in terms of diagnostic yield of PPNs and guide the selection of appropriate diagnostic techniques for different nodules. Trial Registration: ClinicalTrials.gov identifier: NCT06308120.
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