ArticleTranslational pediatrics2025
Gut microbiota-derived 4-hydroxyphenylacetic acid (4-HPAA) inhibits weight gain and is negatively associated with childhood obesity.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Ontogenetic shifts in the metabolomic profiles of Battus polydamas (Lepidoptera: Papilionidae: Troidini) Feeding on Aristolochia gigantea.Journal of chemical ecology · 2026Article
- A microbial metabolite reduces alcohol-induced inflammation via dual modulation of NF-κB and Interferon pathway.bioRxiv : the preprint server for biology · 2026Article
- The Gut-Pancreas Axis in Type 1 Diabetes: Emerging Insights into Microbiota and Immune Interactions.International journal of molecular sciences · 2026Review
- Pivotal gut microbiota and microbial metabolites involved in the regulation of simple obesity.Frontiers in microbiology · 2026Review
- Gut microbiota-immune crosstalk in childhood and adolescent obesity: mechanistic insights and therapeutic potential focused on short-chain fatty acids and emerging metabolites.Frontiers in microbiology · 2026Review
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Authors and funding
7 authors.
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Abstract
Background: Childhood obesity has rapidly increased, becoming a significant global public health concern. Obese children exhibit distinct gut microbiome compositions compared to their normal-weight peers, leading to differences in the metabolic products derived from gut microbiota between the two groups. However, the causal relationship between these microbial-derived metabolites and childhood obesity remains unclear. Therefore, we investigate association between the microbial-derived metabolites and childhood obesity. Methods: In this study, we conducted an analysis of multiple childhood obesity gut microbiota databases. We utilized curated children's microbiota data at the genus level from the GMrepo database. To investigate metabolic pathways, we used the MetOrigin database to analyze the gut microbiota metabolites. Results: We found that the abundances of Conclusions: Our study analyzed the gut microbiota characteristics of obese children across multiple regions and suggests that the downregulation of 4-HPAA may be associated with the development of obese children.
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