ArticleTranslational pediatrics2025
Alterations in the gut microbiota in individuals with infantile cholestasis: a comparison of high- and low-γ-glutamyltransferase subtypes.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Infantile cholestasis caused by pituitary stalk interruption syndrome: a case report and review of the literature.Translational pediatrics · 2026Article
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5 authors.
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Abstract
Background: There are two subtypes of infantile cholestasis (IC): high-γ-glutamyltransferase (GGT) and low-GGT (LG) cholestasis. This study aims to investigate the differences in the gut microbiota between infants with cholestasis and healthy infants and the correlations between the gut microbiota and blood or urine metabolites associated with high-GGT (HG) and LG IC subtypes. Methods: A total of 37 infants were recruited into the cholestasis (Cho) group, including 21 infants with HG and 16 infants with LG levels, with 23 infants included in the control (Con) group. The gut microbiota composition was comprehensively analyzed, as were blood and urine metabolites, clinical indicators, and their correlations. The study was registered in both the Chinese Clinical Trial Registry (www.chictr.org.cn, ChiCTR2300072387) and the National Medical Research Registration & Filing Information System (www.medicalresearch.org.cn, MR-35-24-056613). Results: The Conclusions: Infants with cholestasis exhibit gut microbiota dysbiosis. Notably, distinct differences in the microbiota profiles were observed between the HG and LG cholestasis groups.
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