ArticleJournal of biomedical optics2025
Improved temporal speckle contrast model for slow and fast dynamic: effect of temporal correlation among neighboring pixels.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Laser speckle imaging for biofilm viability assessment: a noninvasive alternative to the MTT assay.Biomedical optics express · 2026Article
- Adapted Correlation Methods for Laser Speckle Imaging of Microbial Activity: Evaluation and Rationale.Sensors (Basel, Switzerland) · 2025Article
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Authors and funding
8 authors.
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Abstract
Significance: Speckle contrast analysis, whether spatial or temporal, is a valuable optical technique extensively utilized in medical and engineering domains owing to its simplicity, affordability, and noninvasive nature. It relies on statistical analysis of the dynamic speckle pattern produced by the sample under examination, offering insights into the sample's dynamics. However, challenges persist in precisely measuring temporal speckle contrast, particularly for slow dynamic samples. Existing mathematical models fail to accurately reflect the experimental data, which could result in misinterpretation of the analyzed results. Aim: To overcome these constraints, we present a mathematical model that incorporates the correlation between adjacent pixels. We specifically concentrate on temporal correlation, i.e., the relationship between neighboring frames, to compute the temporal speckle contrast. Approach: We theoretically replicate the statistical analysis typically conducted to compute temporal speckle contrast in a series of consecutive raw speckle images. Unlike previous models, our calculations account for the potential correlation between neighboring pixels across successive frames. To validate this model, we apply it to the analysis of the dynamics of Results: By considering the probable temporal correlation between neighboring pixels, the proposed model notably improves the precision of temporal speckle contrast measurements, particularly for slow dynamic samples. Analytical expressions for the contrast are derived, incorporating both Gaussian and Lorentzian correlation functions, which exhibit excellent agreement with experimental findings conducted on Conclusions: The proposed model is well-suited for computing temporal contrast in both slow and fast dynamics, rendering it applicable to a wide range of biological and industrial systems.
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Registered trials
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