Evidence map›Paper›PMID 40688168›Full record

ArticleThe Lancet regional health. Western Pacific2025

The association between sexually transmitted infections and pregnancy outcomes in the Northern Territory, Australia: a population-based cohort study.

Jennifer Dunne, Gizachew A Tessema, Matthew Legge, Sylvester Dodzi Nyadanu, Aditi Roy, Amanuel T Gebremedhin, Jacqueline Hendriks, Tricia Reid-Moore, Gavin Pereira

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Article in The Lancet regional health. Western Pacific, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer DunneCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Gizachew A TessemaCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Matthew LeggeCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Sylvester Dodzi NyadanuCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Aditi RoyCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Amanuel T GebremedhinCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Jacqueline HendriksCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Tricia Reid-MooreCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Gavin PereiraCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Often asymptomatic in nature, sexually transmitted infections (STIs) are highly prevalent in women of reproductive ages, leading to adverse perinatal outcomes. This study investigated the association between STIs during pregnancy and the risk of adverse perinatal outcomes using comprehensive population-linked data from the Northern Territory (NT), Australia. Methods: This population-based retrospective cohort study examined births (live births and stillbirths) from the NT Perinatal Data Collection and the NT Notifiable Diseases register from 2005 to 2020. All singleton births (N = 59,465) were included, along with infectious disease notifications of four STIs that occurred during pregnancy: chlamydia, gonorrhoea, trichomoniasis, and syphilis. Relative risks (RR) for associations between STIs during pregnancy with adverse perinatal outcomes (pre-labour rupture of membranes, preterm birth, small-for-gestational age, stillbirth) were estimated using robust Poisson regression models. Findings: For babies born with congenital syphilis (n = 23), there was an association with preterm birth (RR 3.34, 95% confidence interval (CI) 1.80-6.17) and small-for-gestational age (RR 2.22, 95% CI 1.34-3.67). Small-for-gestational age was associated with maternal chlamydia (RR 1.86, 95% CI 1.54-2.24), maternal gonorrhoea (RR 1.76, 95% CI 1.46-2.12), and maternal trichomoniasis (RR 1.10, 95% CI 1.01-1.20). Associations were also observed between gonorrhoea and stillbirth (RR 1.97, 95% CI 1.19-3.27), and trichomoniasis with preterm birth (RR 1.23, 95% CI 1.09-1.39). Interpretation: STIs during pregnancy showed notable associations with adverse birth outcomes. Congenital syphilis most severely affected outcomes, tripling preterm birth risk and doubling small-for-gestational age risk. These findings underscore the importance of addressing barriers to STI screening and treatment prior to and during pregnancy. Funding: National Health and Medical Research Council and the Western Australian Future Health Research and Innovation Fund.

Indexed as

Adverse pregnancy outcomesinfectionsPregnancySexually transmitted

Identifiers

PMID40688168
PMCPMC12271420

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.