ArticleBioactive materials2025
Self-assembled nanosheets of biocompatible polymers as universal cell-membrane mimic to block viral infection.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Supramolecular Polymer-Surfactant Co-Assemblies for Multivalent HSV-1 Inhibition.Angewandte Chemie (International ed. in English) · 2026Article
- Virus-Mediated Self-Assembly of Functional Cyclodextrins for Antiviral Inhibition.Angewandte Chemie (International ed. in English) · 2026Article
- Protein-Linker Co-engineering for Broad-Spectrum Antiviral Development against Enveloped Viruses.ACS materials letters · 2026Article
- Supramolecules for Pathogen Inhibition: From Polymers to Self-Assembled Nanosystems.Accounts of materials research · 2026Article
- Charge-Driven Self-Assembly of Cholesterol Surfactants into Biofunctional Nanodiscs with Antiviral Activity.Angewandte Chemie (International ed. in English) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses cause severe damage to society due to seasonal and pandemic outbreaks; therefore, developing new antivirals is urgently needed. Multivalent virus inhibitors are promising broad-spectrum antivirals, as they can block the initial step of viral infection by mimicking the structure of the cell receptors on the host cell membrane. Biocompatible supramolecular architectures are particularly well-suited for virus inhibition due to the numerous weak non-covalent bindings, resulting in strong yet dynamic multivalent interactions. Herein, we report on supramolecular nanosheets based on dendritic polyglycerol (dPG). The dPG core was functionalized with different ratios of sulfate and mercaptoundecanoic acid (MUA) groups. The MUA, as the hydrophobic part, triggers the self-assembly and -via the acid group-the supramolecular interaction with the virus, while sulfate groups mimic heparan sulfate proteoglycans (HSPG) on the cell membrane for virus interaction. The effect of polymer functionalization degree of MUA (ranging from 30 to 100 %) on the nanosheet size and morphology, as well as their interaction with viral particles, were monitored by cryo-transmission electron microscopy (cryo-TEM) and cryo-electron tomography (cryo-ET). Bio-functional assays such as plaque reduction, pre-infection inhibition, hemagglutination inhibition (HAI) and cell viability assays have been performed to assess the
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.