ArticleBioactive materials2025
Modular assembled biomimetic nanobubbles for synergistic therapy of ischemic stroke
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- A closed-loop myocardial infarction theranostic platform activated by macrophage-derived nitric oxide and acidic microenvironment.Bioactive materials · 2026Article
- Prognostic Value of the Endothelial Activation and Stress Index (EASIX) in Critically Ill Patients With Ischemic Stroke: A MIMIC-IV Database Analysis.Brain and behavior · 2026Article
- Engineering design of platelet-mimicking therapeutic systems: multilevel biomimicry, gating strategies, and translational boundaries.Frontiers in bioengineering and biotechnology · 2026Review
- Targeted delivery of PTX by lactoferrin-modified nanoemulsions for the treatment of glioblastoma.International journal of pharmaceutics: X · 2025Article
- Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence.Journal of clinical medicine · 2025Review
- Natural, Engineered, and Hybrid Platelet Membrane-Based Nanotherapeutics for Inflammatory Diseases.International journal of nanomedicine · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dynamic pathology-adaptive nanodelivery systems represent a promising frontier in acute ischemic stroke (AIS) therapy. Here, we report a thrombo-inflammatory cascade-targeted biomimetic nanobubble engineered through gas-liquid interfacial modular assembly of platelet membranes and immunomodulator fingolimod (FTY720). Molecular dynamics simulations uncovered a gas-liquid interfacial self-organization mechanism driving the ordered spatial distribution of platelet membrane lipid rafts and amphiphilic FTY720 to fabricate platelet membrane coated FTY720 nanobubble (PFNB). Such modular assembled PFNBs can promote the effective presentation of targeted proteins and drug molecular functions on the biointerface, enabling precise sequential lesion targeting, enhanced blood-brain barrier penetration and inflammatory microglial uptake, significantly improving drug delivery efficiency. Therapeutic efficacy analysis
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.