Evidence map›Paper›PMID 40688033›Full record

ArticleComplex & intelligent systems2025

Verticox+: vertically distributed Cox proportional hazards model with improved privacy guarantees.

Florian van Daalen, Djura Smits, Lianne Ippel, Andre Dekker, Inigo Bermejo

Abstract read
In one paragraph

Article in Complex & intelligent systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Florian van DaalenDepartment of Radiation Oncology (MAASTRO), GROW School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID 0000-0002-2229-8587
Djura SmitsNetherlands eScience Center, Amsterdam, The Netherlands.
Lianne IppelMethodology, Statistics Netherlands, Heerlen, The Netherlands.
Andre DekkerDepartment of Radiation Oncology (MAASTRO), GROW School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands.
Inigo BermejoDepartment of Radiation Oncology (MAASTRO), GROW School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Federated learning allows us to run machine learning algorithms on decentralized data when data sharing is not permitted due to privacy concerns. Various models have been adapted to use in a federated setting. Among these models is Verticox, a federated implementation of Cox proportional hazards models, which can be used in a vertically partitioned setting. However, Verticox assumes that the survival outcome is known locally by all parties involved in the federated setting. Realistically speaking, this is not the case in most settings and thus would require the outcome to be shared. However, sharing the survival outcome would in many cases be a breach of privacy which federated learning aims to prevent. Our extension to Verticox, dubbed Verticox+, solves this problem by incorporating a privacy preserving 2-party scalar product protocol at different stages. This allows it to be used in scenarios where the survival outcome is not known at each party. In this article, we demonstrate that our algorithm achieves equivalent performance to the original Verticox implementation. We discuss the changes to the computational complexity and communication cost caused by our additions.

Indexed as

Cox proportional hazard modelFederated learningn-Party scalar product protocolPrivacy preservingVerticox

Identifiers

PMID40688033
PMCPMC12270967

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.