ArticleBioactive materials2025
Multifunctional hydrogel encapsulated with baicalin for full-layer regeneration of drug-resistant bacteria-infected wounds after radiotherapy.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
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- Carrier-free nanoparticles in microneedles disrupt endosomal acidification suppress ferroptosis in radiation-induced oral mucositis.Materials today. Bio · 2026Article
- Multifunctional Hydrogels for Diabetic Wound Healing: Design Strategies and Microenvironmental Remodeling Mechanisms.Gels (Basel, Switzerland) · 2026Review
- An AI-assisted designed supramolecularly engineered nanoplatform reverses pigmentation by triggering an ineffective compensatory melanin production program.Bioactive materials · 2026Article
- Photothermally-activated nano-delivery system for on-demand treatment of diabetic wound infections.International journal of pharmaceutics: X · 2026Article
- Chondroitin Sulfate-Based MPDA@MnOPolymers · 2026Article
- Hydrogels for Healing Radiation-Injured Tissues and Organs.Gels (Basel, Switzerland) · 2026Review
- Synergistic phototherapy and CaBioactive materials · 2026Article
- Functionalized hydrogel sequentially deliver tannic acid and bioactive probiotics for radiation-induced skin injury.Materials today. Bio · 2026Article
- A conductive MXene hydrogel reprograms immunity and autophagy to restore neurovascular repair in infected wounds.Regenerative biomaterials · 2026Article
- Review
- Hydrogels incorporating active compounds from traditional Chinese medicine for diabetic wound healing: mechanistic pathways and bioengineering progress.Frontiers in cell and developmental biology · 2025Review
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Authors and funding
10 authors.
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Abstract
The post-radiotherapy wounds are common in patients. The irradiation-induced reactive oxygen species (ROS) accumulation, nucleic acid damage, and inflammation greatly hinder wound healing. The irradiation-induced immunosuppression may further cause bacterial infection. At present, few dressings are available for infected wounds after radiotherapy (IWAR). In this study, a multifunctional hydrogel for IWAR has been developed by combining a positively-charged antioxidant polymer with the natural product baicalin. This hydrogel can smartly release baicalin under IWAR-like microenvironment and possesses broad-spectrum antibacterial properties. It has effectively prevented irradiation-induced intracellular ROS and nucleic acid damage to protect fibroblasts for tissue repair. In mice treated with IWAR, this hydrogel has inhibited infection caused by drug-resistant
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