Evidence map›Paper›PMID 40687939›Full record

ArticleAmerican journal of preventive cardiology2025

Demographics of lipoprotein(a) and stroke: The UK biobank.

Andrew S Kao, Jonathan Kermanshahchi, Shamim Khosrowjerdi, Alexander C Razavi, Jacqueline Levene, Mikaila Reyes, Parveen Garg, W T Longstreth, Kristiina Rannikmae, Cathie Sudlow and 4 more

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In one paragraph

Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrew S KaoDepartment of Medicine, University of California San Diego, CA, USA.
Jonathan KermanshahchiCalifornia University of Science and Medicine, Colton, CA, USA.
Shamim KhosrowjerdiUniversity of California San Diego School of Medicine, San Diego, CA, USA.
Alexander C RazaviDivision of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
Jacqueline LeveneUniversity of Pittsburgh Medical Center, Heart and Vascular Institute, Pittsburgh, PA, USA.
Mikaila ReyesUniversity of California San Diego School of Medicine, San Diego, CA, USA.
Parveen GargDivision of Cardiovascular Medicine, USC Keck School of Medicine, Los Angeles, CA, USA.
W T LongstrethDepartment of Neurology, University of Washington, Seattle, WA, USA.
Kristiina RannikmaeUniversity of Edinburgh, Usher Institute, Centre for Medical Informatics, Edinburgh, UK.
Cathie SudlowBritish Heart Foundation, Data Science Centre, London, UK.
Michael TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Sotirios TsimikasDivision of Cardiovascular Medicine, University of California San Diego, CA, USA.
Anum SaeedUniversity of Pittsburgh Medical Center, Heart and Vascular Institute, Pittsburgh, PA, USA.
Harpreet S BhatiaDivision of Cardiovascular Medicine, University of California San Diego, CA, USA.

Funding

Aspirin for Primary Prevention of Cardiovascular Disease in Patients with Elevated Lipoprotein(a)K08HL166962 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Harpreet Singh Bhatia · 2023 to 2026
$676k
NHLBI NIH HHS K08 HL166962
6 · The paper itself

Abstract

Introduction: Lipoprotein(a) [Lp(a)] is associated with ischemic stroke, but the strength of association based on demographic differences remains unclear. We aimed to investigate the association between Lp(a)>125 nmol/L and stroke by age, sex, and racial/ethnic subgroups. Methods: Using data from the UK Biobank, we included 353,309 participants with an Lp(a) measurement without a history of atherosclerotic cardiovascular disease (ASCVD). Stroke was defined as ischemic stroke or hemorrhagic stroke (with subtypes subarachnoid hemorrhage and intracerebral hemorrhage). Cox proportional hazards models were used to evaluate the association between elevated Lp(a) and stroke (ischemic or hemorrhagic), adjusted for ASCVD risk factors, race/ethnicity, lipid lowering therapy, antiplatelet and anticoagulation medications. Outcomes were defined using ICD-10 codes. Results: The study population consisted of 55.7 % women and 94 % White individuals with average age of 56 years. The median Lp(a) level was 20.9 [IQR 9.5, 61.4] nmol/L and prevalence of Lp(a) >125 nmol/L was 11.1 % ( Conclusion: Lp(a) is independently associated with ischemic stroke, with variation by sex but not age or race/ethnicity. Lp(a) was not significantly associated with hemorrhagic stroke.

Indexed as

Lipoprotein(a)PreventionRisk factorsStroke

Identifiers

PMID40687939
PMCPMC12273577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.