ArticleJournal of virus eradication2025
The impact of magnitude and duration of plasma viremia during analytical treatment interruptions on CD4
Article in Journal of virus eradication, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Objective: Analytical treatment interruption (ATI) is crucial for assessing the efficacy of HIV-1 cure strategies. Recent cure studies have implemented more flexible ART restart criteria, permitting higher plasma viral loads (pVLs) for longer periods, which could potentially impair CD4 Design: We conducted a pooled analysis of six clinical HIV cure trials that included an ATI to evaluate the impact of magnitude and duration of plasma viremia during ATI on CD4 Methods: Wilcoxon signed-rank or rank-sum test was used to analyze differences in CD4 Results: Among 114 participants, we found no change in CD4 Conclusion: In our pooled analysis, high peak rebound pVLs and longer duration of viremia did not impair CD4
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