ArticleFrontiers in microbiology2025
Characterization of vaginal microbiota across female reproductive phases.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Vaginal Ecosystem During Gestation and Puerperium: Microbiota, Dysbiosis, Infection and Fetal-Maternal Implications.Microorganisms · 2026Review
- The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Chemotaxis and selective interactions ofbioRxiv : the preprint server for biology · 2026Article
- Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The vaginal microbiota plays a crucial role in women's reproductive health, but its composition and function throughout different female reproductive phases remain poorly understood. This study aimed to investigate the dynamic variations in vaginal microbial communities corresponding to different hormonal states throughout the female reproductive phase. Methods: Vaginal samples were collected from 150 healthy women across five reproductive phases: follicular phase, luteal phase, early pregnancy, lactation, and menopause (30 samples per group). 16S rRNA sequencing was used to analyze the microbial composition. Alpha and beta diversity analyses were performed, and random forest models were constructed to identify key microbial taxa associated with each phase. Functional profiling was conducted using Clusters of Orthologous Groups of Proteins (COG) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Results: Microbial communities show significant variations across the different reproductive phases. Conclusion: Our study reveals dynamic variations in vaginal microbiota across reproductive phases, closely linked to hormonal states, and highlights potential microbial targets for enhancing women's reproductive health.
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