Evidence map›Paper›PMID 40687834›Full record

ArticleiScience2025

Dynamic changes in chromatin accessibility within one month of mouse intracerebral hemorrhage.

Rong Xiang, Kang OuYang, Junmin Wang, Zhan Chen, Jin Tao, Xinru Zhang, Houlian Zhang, Zhiyun Li, Luyao Wang, Ruoqi Ding and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rong XiangCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Kang OuYangCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Junmin WangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhan ChenCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Jin TaoDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xinru ZhangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Houlian ZhangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhiyun LiDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Luyao WangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Ruoqi DingDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Chuanyu LiuBGI Research, Shenzhen 518083, China.
Jun XieShanxi Medical University-BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China.
Yong HouCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Jian WangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Longqi LiuCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Mingyue WangBGI Research, Hangzhou 310030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a severe stroke subtype associated with high mortality and disability. Understanding the molecular and cellular mechanisms behind ICH is vital for developing effective therapeutic interventions. We utilized a single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq) to profile changes in chromatin accessibility over the first month following ICH in murine models. We examined 262,506 cells, identifying 77,978 upregulated and 35,023 downregulated candidate

Indexed as

genomics

Identifiers

PMID40687834
PMCPMC12270706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.