Evidence map›Paper›PMID 40687802›Full record

ArticleiScience2025

Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.

Fatemeh Fazlali, Rafael Lazar, Faady Yahya, Christian Epple, Manuel Spitschan, Oliver Stefani, Christian Cajochen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatemeh FazlaliPsychiatric Hospital of the University of Basel, Basel, Switzerland, Centre for Chronobiology, Basel, Switzerland.
Rafael LazarPsychiatric Hospital of the University of Basel, Basel, Switzerland, Centre for Chronobiology, Basel, Switzerland.
Faady YahyaDepartment of Ophthalmology, University of Basel, Basel, Switzerland.
Christian EpplePsychiatric Hospital of the University of Basel, Basel, Switzerland, Centre for Chronobiology, Basel, Switzerland.
Manuel SpitschanTechnical University of Munich, TUM School of Medicine and Health, Munich, Germany.
Oliver StefaniLucerne University of Applied Sciences and Arts, School of Engineering and Architecture, Horw, Switzerland.
Christian CajochenPsychiatric Hospital of the University of Basel, Basel, Switzerland, Centre for Chronobiology, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light exposure at night can suppress melatonin production and increase alertness, primarily through the action of melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). This study investigated whether cone photoreceptors also influence melatonin suppression and subjective alertness using non-visual metameric light. Forty-eight participants with normal trichromatic vision were exposed to three lighting conditions: a baseline (BL: 9 lx

Indexed as

Cell biologyHealth sciencesSensory neuroscience

Identifiers

PMID40687802
PMCPMC12273515

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.