Evidence map›Paper›PMID 40687778›Full record

ArticleiScience2025

Unraveling the aging-reversal potency of stem cell-derived extracellular vesicles in a rat model of premature cardiac senescence.

Lidia Gómez-Cid, Alexia Campo-Fonseca, Mar Cervera-Negueruela, Alejandra Ocampo, Ángel Pinto, Juan Miguel Gil-Jaurena, Susana Suárez-Sancho, Francisco Fernández-Avilés, Lilian Grigorian-Shamagian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lidia Gómez-CidDepartamento de Bioingeniería, IiSGM, Universidad Carlos III de Madrid, 28911 Leganés, Spain.
Alexia Campo-FonsecaDepartamento de Bioingeniería, IiSGM, Universidad Carlos III de Madrid, 28911 Leganés, Spain.
Mar Cervera-NegueruelaDepartamento de Bioingeniería, IiSGM, Universidad Carlos III de Madrid, 28911 Leganés, Spain.
Alejandra OcampoUnidad de Producción Celular, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain.
Ángel PintoHospital General Universitario Gregorio Marañón, 28009 Madrid, Spain.
Juan Miguel Gil-JaurenaHospital General Universitario Gregorio Marañón, 28009 Madrid, Spain.
Susana Suárez-SanchoUnidad de Producción Celular, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain.
Francisco Fernández-AvilésFaculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Lilian Grigorian-ShamagianCardiology Department, San Rafael University Hospital, Universidad Francisco de Vitoria, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiosphere-derived cells (CDCs) and their extracellular vesicles (CDC-EVs) can rejuvenate and improve cardiac function, but their efficacy varies among donors. This study aimed to identify predictors of CDC-EV potency. CDCs from human donors were analyzed for phenotypical and biological properties. The anti-aging activity of CDC-EVs was tested using an

Indexed as

Biological sciencesBiological sciences research methodologiesCell biology

Identifiers

PMID40687778
PMCPMC12271077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.