Evidence map›Paper›PMID 40687765›Full record

ArticleMeasurement : journal of the International Measurement Confederation2025

Development of Time-Resolved Luminescence Measurement Instruments for Biosensing and Bioimaging - An Overview.

Benjamin Sreenan, Vala Kafil, Donovan Wells, Gita Kharal, Tanner Hunt, Alim Gulbag, Jeongwon Park, Hao Xu, Mohamed Sanad, M Sami Fadali and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Measurement : journal of the International Measurement Confederation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Benjamin SreenanDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Vala KafilDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Donovan WellsDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Gita KharalDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Tanner HuntDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Alim GulbagDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Jeongwon ParkDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Hao XuDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Mohamed SanadDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
M Sami FadaliDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.
Yunfang JiaCollege of Electronic Information and Optical Engineering, Nankai University, Tianjin 300071, PR China.
Qingsu ChengDepartment of Biomedical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
David AuCoinDepartment of Microbiology and Immunology, University of Nevada Reno, Reno, NV, 89577, USA.
Lawrence W MillerDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
Xiaoshan ZhuDepartment of Electrical and Biomedical Engineering, University of Nevada Reno, Reno, NV, 89577, USA.

Funding

Time-Gated Fluorescence Lateral Flow Immunoassay for Melioidosis DiagnosisR15GM135855 · NIGMS · UNIVERSITY OF NEVADA RENO · PI ZHU, XIAOSHAN · 2020 to 2020
$426k
NIGMS NIH HHS R15 GM135855
6 · The paper itself

Abstract

Time-resolved luminescence measurement (TRLM) leverages luminescent probes with long (> 100 nanoseconds) emission decay times to enable high-contrast biosensing and bioimaging. TRLM detects probe signals after a brief delay that follows pulsed excitation. This pulse-delay-detect scheme virtually eliminates excitation light scattering and nanosecond-scale emissions from sample autofluorescence to yield measurements with exceptional signal-to-background ratios. A wide array of probes with decay times ranging from tens of microseconds to several milliseconds have been developed for TRLM, including organic dyes, lanthanide complexes, Mn-doped quantum dots, persistent luminescence nanoparticles, silicon quantum dots, and others. Meanwhile, with the recent advance in light excitation sources, photo detectors and electronic devices, various time-resolved luminescence instruments using such probes for biological applications have been reported. There are several critical reviews on the progress of luminescence-long-lived probes, however, there has been lacking a review on these instruments. This review aims to (1) present the recent development and applications of such instruments for luminescence-long-lived probes, as well as the instrument development trend towards in-field or POC applications, and (2) elucidate how the complexity, cost, compactness, and performance of TRLM instruments were affected by the optical properties of luminescence-long-lived probes. We believe that this review will bring more attention to researchers about a clear comprehension of TRLM instruments and urge researchers to further advance TRLM instruments towards low-cost, compact, and high-performance instruments for broader biosensing/imaging applications.

Identifiers

PMID40687765
PMCPMC12273837

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.