ArticleEClinicalMedicine2025
Temporal dynamics in the association between depression and dementia: an umbrella review and meta-analysis.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies.Frontiers in public health · 2026Pooled it
- Depressive and insomnia symptoms and incident dementia risk: A 12-year study in U.S. older adults.Journal of affective disorders · 2026Article
- Plasma GFAP modifies the association of depressive symptoms with cognitive function: A population-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Considerations in Alzheimer's Disease in Women.Current neurology and neuroscience reports · 2026Review
- Global, regional, and national burden of dementia attributable to mood disorders: a comparative risk assessment study.The journal of prevention of Alzheimer's disease · 2026Article
- Depressive symptoms as a risk factor or prodrome of dementia: multi-state cognitive transitions modified by age and polygenic risk.The journal of prevention of Alzheimer's disease · 2026Article
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- Trajectory of depression occurrence before, during, and after dementia diagnosis: A population-based study.Translational psychiatry · 2026Article
- Associations of Apathy and Depressive Symptoms With Frailty Domains in Individuals Aged 75 Years Old: A Cross-Sectional Study.Geriatrics & gerontology international · 2026Article
- The Potential Role of SGLT2 Inhibitors in the Treatment of Depression: Mechanisms and Clinical Prospects.Drug design, development and therapy · 2026Review
- Joint trajectories of loneliness and depressive symptoms and risk of incident osteoporosis among middle-aged and older adults: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Cumulative and variable depression symptom exposure and incident dementia: Panel data analysis of four longitudinal cohort studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Informing depression-specific dementia risk models: An evidence-based analysis of moderators of the depression-dementia association.Alzheimer's & dementia (New York, N. Y.)Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Identifying modifiable risk factors is crucial for dementia prevention, a global health concern. Depression is considered a risk factor for dementia, but the temporal dynamics across the life course remain inconclusive. Therefore, we aimed to systematically assess the relationship between the timing of depression assessment and risk of all-cause late-life dementia. Methods: We conducted an umbrella review and meta-analysis to assess incident dementia in individuals with non-current history of depression. PubMed and Ovid Embase, MEDLINE, and PsycInfo were searched from inception up to February 17, 2025. Systematic reviews with meta-analyses investigating the association between depression and incident late-life dementia were included. From eligible reviews, we also extracted data from studies reporting dementia risk as hazard ratios (HRs), analysing the timing of depression measurement using random-effects models for meta-analysis. This study is registered with PROSPERO, CRD42021249706. Findings: Of the 7763 records identified, nine reviews were eligible for inclusion of the umbrella review. One review was judged to be of moderate quality, while the others were either low ( Interpretation: The findings suggest that depression across the life course may increase dementia risk; however, substantial heterogeneity and review quality should be considered when interpreting the strength of this evidence. A life course approach to the treatment and prevention of depression may help reduce the burden of dementia, but this will require scaling up access to effective mental health care for vulnerable populations. Further research is needed to clarify if the stronger late-life association reflects depression as an immediate risk factor or an early manifestation of neurodegenerative processes. Funding: National Institute for Health and Care Research, UK Research and Innovation, and Saudi Arabian Cultural Mission.
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Registered trials
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