ArticleFrontiers in medicine2025
The research on cycloastragenol in the treatment of brain metastases from lung cancer: mechanistic exploration of radiotherapy sensitization and amelioration of brain injury.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to investigate the radiosensitizing and toxicity-reducing effects of Cycloastragenol (CAG) in the radiotherapy of lung cancer brain metastases. Methods: A brain metastasis model of lung cancer was established using stereotactic brain localization. After successful modeling, varying doses of CAG (5 mg/kg, 10 mg/kg, 20 mg/kg) were administered via intraperitoneal injection to evaluate its antitumor efficacy. Radiotherapy (3 Gy per session, total 10 sessions) was combined with CAG (20 mg/kg) to assess its radiosensitizing effects. Small-animal Results: 1. CAG significantly suppressed the growth of Lewis lung carcinoma (LLC) brain xenografts. 2. CAG markedly enhanced the radiotherapeutic efficacy against lung cancer brain metastases. 3. CAG ameliorated radiation-induced brain injury in tumor-bearing mice by attenuating pro-inflammatory polarization of microglia/macrophages. 4. CAG inhibited the activity of the JAK/STAT signaling pathway in LLC brain tumor tissues, thereby downregulating the expression of neutrophil chemotaxis-associated cytokines, including CXCL3 and CCL5. 5. CAG alleviated radiation-induced brain injury in tumor-bearing mice by suppressing the IKK/NF-κB signaling pathway in LLC brain tumor tissues, which further modulated microglial/macrophage pro-inflammatory polarization. Conclusion: CAG ameliorates neuroinflammation, enhances the therapeutic efficacy of radiotherapy for lung cancer brain metastases, and mitigates radiation-induced brain tumor injury by suppressing the activity of the JAK/STAT and IKK/NF-κB signaling pathways within metastatic lesions.
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