Evidence map›Paper›PMID 40687611›Full record

ArticleGenes & diseases2025

The targeting of AKR1C1 synergizes with gefitinib via the STAT3 signaling pathway in

Linlin Chang, Shuzhen Wei, Xiaotian Qi, Yang Gao, Jinhua Chen, Yu Cui, Pengxing He, Wenzhou Zhang

Abstract read
In one paragraph

Article in Genes & diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linlin ChangDepartment of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Henan Engineering Research Center for Tumour Precision Medicine and Comprehensive Evaluation, Henan Cancer Hospital, Henan Provincial Key Laboratory of Anticancer Drug Research, Zhengzhou, Henan 450008, China.
Shuzhen WeiSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Xiaotian QiKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong 261053, China.
Yang GaoDepartment of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Henan Engineering Research Center for Tumour Precision Medicine and Comprehensive Evaluation, Henan Cancer Hospital, Henan Provincial Key Laboratory of Anticancer Drug Research, Zhengzhou, Henan 450008, China.
Jinhua ChenDepartment of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Henan Engineering Research Center for Tumour Precision Medicine and Comprehensive Evaluation, Henan Cancer Hospital, Henan Provincial Key Laboratory of Anticancer Drug Research, Zhengzhou, Henan 450008, China.
Yu CuiDepartment of Hematopathy, Henan Institute of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan 450008, China.
Pengxing HeSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Wenzhou ZhangDepartment of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Henan Engineering Research Center for Tumour Precision Medicine and Comprehensive Evaluation, Henan Cancer Hospital, Henan Provincial Key Laboratory of Anticancer Drug Research, Zhengzhou, Henan 450008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40687611
PMCPMC12272410

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.