Evidence map›Paper›PMID 40687605›Full record

ArticleBrain communications2025

Morphometric characteristics of tibial nerve and their relationship with age.

Shahram Oveisgharan, Armand Collin, Jingyun Yang, Sue E Leurgans, Veronique VanderHorst, David A Bennett, Julien Cohen-Adad, Osvaldo Delbono, Aron S Buchman

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shahram OveisgharanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-6841-4830
Armand CollinInstitute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Sue E LeurgansRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Veronique VanderHorstDivision of Movement Disorders, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID https://orcid.org/0000-0003-3689-554X
Julien Cohen-AdadInstitute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.
Osvaldo DelbonoDepartment of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0002-1613-8202
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-6426-2742

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Identifying resilience proteins in key motor tissues that drive motor and cognitive decline and offset the negative effects of ADRD pathologies within and outside the brainR01AG075728 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARON S BUCHMAN · 2022 to 2026
$6.9M
Role of Central Autonomic Relays in Aging SarcopeniaR01AG071545 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Osvaldo Delbono · 2022 to 2026
$2.9M
NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG071545NIA NIH HHS R01 AG075728
6 · The paper itself

Abstract

Peripheral nerve comprises a crucial component of the distributed motor/sensory system. However, there is a paucity of data on peripheral nerve morphology derived from large numbers of older adults. This study aimed to quantify the morphometric characteristics of myelinated nerve fibres of the tibial nerve obtained from deceased community-dwelling older adults and examine their association with age. The tibial nerves were obtained from consecutive autopsies of older adults without a history of diabetes who were participants of the Rush Memory and Aging Project, an ongoing longitudinal clinical-autopsy study. A nerve fascicle, obtained from a fixed popliteal segment of the tibial nerve, was separated from the blood vessels and adipose tissue for postmortem examination under an optical microscope. Morphometric characteristics of the myelinated nerve fibres were automatically segmented and quantified using our open-source software

Indexed as

agingmorphometrymyelinated nerve fibrestibial nerve

Identifiers

PMID40687605
PMCPMC12272163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.