ArticleHealth science reports2025
Effect of Neoatherosclerosis and Intervention-Associated Neoatheroma Rupture on Clinical Outcomes in Patients With In-Stent Restenosis: A Retrospective Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Treatment of drug-eluting stents (DES) in-stent restenosis (ISR) was challenging. Neoatherosclerosis (NA) occurs earlier and more frequently in DES-ISR. This study aims to analyze the effect of neoatheroma morphology and intervention-associated neoatheroma intima rupture on intervention strategies and clinical outcomes in patients with DES-ISR. Methods: We retrospectively analyzed 56 consecutive patients with symptomatic DES-ISR and optical coherence tomography (OCT) verified in-stent NA who had been treated by repeat stenting or drug-coated balloon (DCB). Patients were divided into two groups according to whether there was severe neoatheroma intima rupture (SNIR) after balloon angioplasty. Characteristics of the neointima were analyzed. Intervention strategies and clinical outcomes were compared between the two groups. Results: SNIR occurred in 29 patients after balloon angioplasty. Repeat stenting was more frequent in these patients (48.3% vs. 7.4%, Conclusions: Intervention-associated severe neoatheroma rupture increased the risk of recurrent TLR, repeat stenting was more effective than DCB in such patients. Neoatherosclerosis with a significant lipid pool is closely related to intervention-associated SNIR.
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