ArticleACS environmental Au2025
Toxicological and Functional Assessment of Minicell-Encapsulated dsRNA on Biocontrol Agents in Agriculture.
Article in ACS environmental Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The unfulfilled potential of nanocarriers for RNA delivery in antiviral crop protection.Nature plants · 2026Review
- Taxonomic Restructuring of Rhizosphere Guilds is Driven By Agricultural Management and Scion Genotype in Apple.Microbial ecology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Double-stranded RNA (dsRNA)-based biopesticides represent promising tools for target-oriented pest and pathogen control. However, their compatibility with beneficial organisms used in biological control programs is not clear. In this study, the potential interactions between two dsRNA formulationsnaked and minicell-encapsulated (ME-dsRNA)and different commercialized bacterial, fungal, and insect biocontrol agents (BCAs) were examined. There was no toxicity of either of the two dsRNA formulations toward , , or , based on growth assays. ME-dsRNA significantly enhanced fungal BCA growth, likely due to improved uptake or protection. Coapplication trials on strawberry fruit and foliage showed that coapplication of dsRNA and BCAs was efficacious with no evidence of synergistic or antagonistic effects. Insect bioassays demonstrated that dsRNA sprays had no adverse effects on predatory mite populations ( and ). Additionally, in silico off-target analysis detected minimal potential matches in and , none of which corresponded to in vivo toxicity. Markedly, greenhouse and in vitro assays confirmed that neither dsRNA formulation interfered with the biocontrol efficacy of BCAs on in strawberry. Overall, this study provides strong evidence that dsRNA-based products, including ME-dsRNA, are compatible with key BCAs and pose minimal ecological risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.