Evidence map›Paper›PMID 40687502›Full record

ReviewACS environmental Au2025

Surface-Enhanced Raman Spectroscopy (SERS) Based Biological and Environmental 2D and 3D Imaging.

Qishen Huang, Huiyuan Guo, Wei Wang, Seju Kang, Peter J Vikesland

Abstract readReview
In one paragraph

Review in ACS environmental Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qishen HuangSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.ORCID https://orcid.org/0000-0002-8493-5799
Huiyuan GuoDepartment of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, United States.ORCID https://orcid.org/0000-0001-9524-5251
Wei WangSchool of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID https://orcid.org/0000-0002-6231-2216
Seju KangEawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf CH-8600, Switzerland.ORCID https://orcid.org/0000-0003-3281-4829
Peter J VikeslandCivil and Environmental Engineering and Institute of Critical Technology and Applied Science (ICTAS) Sustainable Nanotechnology, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID https://orcid.org/0000-0003-2654-5132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surface-enhanced Raman spectroscopy (SERS) imaging is a highly sensitive, spatially resolved tool for biological and environmental analysis. SERS imaging combines molecular fingerprinting with real-time, in situ detection, with the capacity to address key questions around analyte identification, concentration, and distribution. In biological systems, SERS imaging has enabled sensitive detection of nucleic acids, proteins, and biomarkers. Notable progress includes the detection of miRNAs through nanoassembly and disassembly techniques, as well as bioorthogonal chemistry and antibody-conjugated methods for protein and enzyme imaging. These approaches, along with integration of complementary imaging techniques, have improved SERS imaging for in vivo studies in plant and animal cells. Additionally, SERS imaging of pathogens reveals their distribution and behavior in cellular environments. For environmental applications, SERS imaging has been used to track pesticides, nanoparticles, and heavy metal ions, providing critical insights into contaminant transport and transformation. Furthermore, SERS-based pH and reactive oxygen species (ROS) imaging delivers spatially resolved data on reactive species in biological and environmental microenvironments, aiding in understanding their dynamic roles in various processes. Despite its advantages, SERS imaging faces several challenges. By addressing its limitations, SERS imaging holds promise for broad application in contaminant monitoring, clinical diagnostics, and real-time biological analysis.

Indexed as

analytical methodsbiological sensingenvironmental sensingimagingmicroenvironmentsnanoprobesnanostructuresSERS

Identifiers

PMID40687502
PMCPMC12272281

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.