ArticleBiomaterials and biosystems2025
Substrate stiffness and pressure alter retinal Müller glia response and extracellular matrix production.
Article in Biomaterials and biosystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Whale Müller glia create a permissive environment supporting retinal ganglion cell survival and neurite outgrowth.iScience · 2026Article
- Shear Stress as a Driver of Retinal Müller Glia Survival and Fibrotic Reprogramming.Cell biochemistry and function · 2026Article
- Resilience to Diabetic Retinopathy (RDR) Is Associated with a Pre-Retinopathy Transcriptional Program Induced by Diabetes.Biomolecules · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The retina is highly influenced by its mechanical environment, with Müller glia (MG) acting as key mechanosensors and extracellular matrix (ECM) producers. This study examined MG responses to substrate stiffness and high pressure (HP), and whether TGF-β1 modulation could mitigate these effects. Methods: Primary MG from adult rat retinas were cultured on glass (Young's modulus E'= Results: On glass and 100 kPa gels, MG survival, cell area, and ECM deposition (collagen I, IV, and fibronectin) increased, with cells adopting a fusiform shape and more dedifferentiated state. Under HP, survival decreased on stiffer substrates, though cell area and morphology remained unchanged. HP increased ECM deposition, which was reduced by TGF-β1 inhibition. Conclusions: Our findings suggest that MG response to mechanical stress alter their survival and cell area, and increases ECM secretion, highlighting TGF-β1 as a potential therapeutic target.
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