ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2025
Assessment of Serum Autophagy Related Protein Beclin-1 in Egyptian Adult Beta Thalassemia Patients.
Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Beclin-1 has a significant role in autophagy process (Macro-autophagy). It functions through interaction with autophagy-related genes (Atgs) and other protein molecules during the process of autophagy.Here we assessed the level of serum autophagy related protein Beclin-1 in Egyptian adult beta thalassemia patients and studied its relation to ineffective erythropoiesis, transfusion requirements, iron overload.This case control study included 50 Egyptian adult beta thalassemia patients aged 18 years or more including transfusion dependent and non-transfusion dependent patients, and 25 healthy controls. The patients were selected from the Hematology Department of Ain Shams University Hospitals, Cairo, Egypt.The median (IQR) Beclin-1 level was higher in patients group in comparison to control group with highly significant statistical difference {15ng/ml (13-22) Vs 2.5ng/ml (2-3), p value < 0.001}. We found a statistically significant positive correlation between Beclin-1 level and serum ferritin (
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