Evidence map›Paper›PMID 40687430›Full record

ArticleFrontiers in oncology2025

Association between genomic features and toxic metal(loid) accumulation in left-sided and right-sided colorectal cancer.

Shoujiang Yu, Min Fu, Yurong Wang, Ling Lin, Shushen Ji, Feng Du, Li Song, Mengzhu Wang, Yufeng Zhai, Jiangman Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shoujiang Yu *Ward I of Department of General Surgery, the First People's Hospital of Pingdingshan, the First Hospital Affiliated to Pingdingshan University, Pingdignshan, Henan, China.
Min Fu *Department of Oncology, Nanyang Second People's Hospital, Nanyang, Henan, China.
Yurong Wang *Department of Clinical Laboratory, Nanjing Jiangbei Hospital, Nanjing, China.
Ling Lin *Shanghai Biotecan Medical Laboratory Co., Ltd., Shanghai Zhangjiang Institute of Medical Innovation, Shanghai, China.
Shushen JiShanghai Biotecan Medical Laboratory Co., Ltd., Shanghai Zhangjiang Institute of Medical Innovation, Shanghai, China.
Feng DuDepartment of Oncology, Nanyang Second People's Hospital, Nanyang, Henan, China.
Li SongShanghai Biotecan Medical Laboratory Co., Ltd., Shanghai Zhangjiang Institute of Medical Innovation, Shanghai, China.
Mengzhu WangShanghai Biotecan Medical Laboratory Co., Ltd., Shanghai Zhangjiang Institute of Medical Innovation, Shanghai, China.
Yufeng ZhaiShanghai Biotecan Medical Laboratory Co., Ltd., Shanghai Zhangjiang Institute of Medical Innovation, Shanghai, China.
Jiangman ZhaoShanghai Biotecan Medical Laboratory Co., Ltd., Shanghai Zhangjiang Institute of Medical Innovation, Shanghai, China.
Min HuangDepartment of Respiration, Huanghe Sanmenxia Hospital Affiliated to Henan University of Science and Technology, Sanmenxia, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) is a high heterogenous disease of genetic variations, which was influenced by tumor anatomic location and toxic metal(loid) accumulation. Current study aims to investigate genomic heterogeneity of CRC influenced by toxic metal(loid) accumulation based on tumor anatomic location. Methods: In this study, a total of 94 patients with CRC were recruited including 69 left-sided tumors and 35-right sided tumors. The genomic mutation landscape and microsatellite instability (MSI) of tumors were analyzed. The blood metal(loid) element levels were tested by inductively coupled plasma emission spectrometry (ICP-MS). Results: A total of 642 somatic variations across 24 genes were identified in 94 CRC patients. The most frequently mutated genes were Conclusions: This study presented the comprehensive genomic landscape of 94 CRC patients according to tumor anatomic location. The blood toxic metal(loid) accumulation may have potential influence on genomic features.

Indexed as

anatomical locationcolorectal cancermetal(loid)microsatellite instabilitynext-generation sequencing

Identifiers

PMID40687430
PMCPMC12270859

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.