ArticleCureus2025
Unmasking Histoplasmosis: A Diagnostic Challenge of Pediatric Febrile Neutropenia in an Immunocompromised Patient.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histoplasmosis is an infection caused by a dimorphic fungus. Disseminated disease in children is described mainly in infants under two years of age, but can be particularly aggressive in immunocompromised patients. We report the case of a six-year-old girl with B-cell acute lymphoblastic leukemia (ALL) who presented with fever of unknown origin, respiratory symptoms, hepatosplenomegaly, and pancytopenia. She was admitted to the hospital with febrile neutropenia and exhibited a progressively worsening clinical course. Initial work-up, including laboratory and imaging studies, failed to identify a clear infectious source. Due to signs of respiratory compromise, a chest computed tomography (CT) was performed, revealing interstitial pneumonia. A bone marrow aspirate subsequently identified intracellular budding yeast, which was confirmed as
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