ArticleCureus2025
Serum Progranulin as a Potential Diagnostic Predictor in Neonatal Sepsis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study aimed to evaluate the diagnostic and prognostic power of progranulin (PGRN) in neonatal sepsis.
methodsWe enrolled 67 newborns hospitalized for sepsis or suspected infection. Serum biomarkers, including PGRN, were quantified at admission. The relationship between PGRN levels and sepsis severity, hospital stay duration, and diagnostic accuracy was analyzed.
resultsNeonates with sepsis exhibited elevated PGRN concentrations, which correlated directly with prolonged hospitalization. PGRN emerged as a robust prognostic biomarker for neonatal sepsis, indicating the highest predictive power (AUC: 0.956; 95% CI: 0.875-0.991;
conclusionThis study indicated that PGRN may be an excellent biomarker for early diagnosis and guiding clinical management of neonatal sepsis.
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