ArticleJournal of pain research2025
Electroacupuncture and Parecoxib Reduce Inflammatory Injury in a Primary Dysmenorrhea Rat Model: Investigating the Role of the COX-2/NF-κB/NLRP3 Pathway.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Ge-Gen Decoction Modulates the HSP90/AKT Signaling Pathway and the NLRP3 Inflammasome to Alleviate Primary Dysmenorrhea.Journal of pain research · 2026Article
- Endogenous mediators in regulating primary dysmenorrhea.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Purpose: Anti-inflammatory drugs relieve primary dysmenorrhea (PDM), and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) is a potential treatment target. Electroacupuncture (EA) is an effective alternative strategy for treating PDM as it regulates the NLRP3 inflammasome. However, the exact anti-inflammatory mechanism of EA remains unclear. Therefore, this study explored the therapeutic effect of EA on PDM and determined the potential involvement of the cyclooxygenase-2 (COX-2)/nuclear factor κB (NF-κB)/NLRP3 signaling pathway. Patients and Methods: The following pain management interventions were administered to a PDM rat model: saline (control), EA, parecoxib, EA + parecoxib, or ibuprofen. After treatment, the following parameters were examined: torsion behavior; endometrial histopathological morphology and ultrastructure; serum and uterine prostaglandin E Results: The treatment groups showed considerably reduced pathological uterine injury compared with that of the control. This was associated with decreased PGF Conclusion: Our findings demonstrated superior anti-inflammatory effects of EA + parecoxib on COX-2/NF-κB/NLRP3 signaling pathway-related proteins compared with that of EA alone or single-drug administration.
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