Evidence map›Paper›PMID 40687305›Full record

ArticlePhysics and imaging in radiation oncology2025

Comparison of proton and photon therapy in stereotactic arrhythmia radioablation for ventricular tachycardia.

Keyur D Shah, Chih-Wei Chang, Pretesh Patel, Sibo Tian, Yuan Shao, Kristin A Higgins, Yinan Wang, Justin Roper, Jun Zhou, Zhen Tian and 1 more

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Keyur D ShahDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Chih-Wei ChangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Pretesh PatelDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Sibo TianDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Yuan ShaoSchool of Public Health, University of Illinois, Chicago, IL, USA.
Kristin A HigginsDepartment of Radiation Oncology, City of Hope Cancer Center Atlanta, Atlanta, GA, USA.
Yinan WangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Justin RoperDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Jun ZhouDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Zhen TianDepartment of Radiation & Cellular Oncology, University of Chicago, Chicago, IL, USA.
Xiaofeng YangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Funding

Real-time Volumetric Imaging for Motion Management and Dose Delivery VerificationR01CA272991 · NCI · EMORY UNIVERSITY · PI Zhen Tian, Xiaofeng Yang · 2023 to 2026
$2.3M
Artificial Intelligence Driven Automatic Treatment Planning of Stereotactic Radiosurgery for the Management of Multiple Brain MetastasesR37CA272755 · NCI · UNIVERSITY OF CHICAGO · PI Zhen Tian · 2022 to 2026
$1.8M
NCI NIH HHS R01 CA272991NCI NIH HHS R37 CA272755
6 · The paper itself

Abstract

Background and Purpose: Ventricular tachycardia (VT) is a life-threatening arrhythmia commonly treated with catheter ablation; however, some cases remain refractory. Stereotactic arrhythmia radioablation (STAR) offers a non-invasive alternative. While photon-based STAR is effective, proton therapy may improve dose conformity and spare critical organs at risk (OARs), including the heart itself. The aim of this study was to compare the dose-volume metrics between proton and photon therapy for VT. Materials and Methods: We retrospectively analyzed 34 VT patients who received photon STAR. Proton STAR plans were generated using robust optimization in a commercial treatment planning system to deliver the same prescription dose of 25 Gy in a single fraction. Dose-volume metrics, including Results: Proton and photon plans achieved comparable target coverage, with CTV Conclusion: Proton therapy for STAR demonstrated significant potential for OARs sparing compared to photon therapy for VT, while maintaining equivalent target coverage. These findings highlight the potential of proton therapy to improve outcomes for VT patients.

Indexed as

Dose-Volume AnalysisProton TherapySTARVentricular Tachycardia

Identifiers

PMID40687305
PMCPMC12274703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.