ArticleFrontiers in public health2025
Frailty and risk of gastrointestinal bleeding: a prospective cohort study based on UK biobank.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Age-related differences in the presentation, management, and outcomes of lower gastrointestinal bleeding: a retrospective multinational cohort study.The Lancet regional health. Europe · 2026Article
- Determinants of clinical outcome after transarterial embolization for nonvariceal gastrointestinal bleeding: a retrospective cohort study.BMC surgery · 2026Article
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Authors and funding
9 authors.
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Abstract
Introduction: Frailty has been associated with various diseases. However, its impact on gastrointestinal bleeding (GIB) remains largely unexplored. This study investigates the relationship between frailty and the incidence of gastrointestinal bleeding events. Methods: A total of 352,060 participants from the UK Biobank with no history of gastrointestinal bleeding were included. Baseline frailty status was assessed using the Fried phenotype and categorized as non-frail, pre-frail, or frail. The primary outcome was gastrointestinal bleeding, identified through hospitalization records and death registries. Cox proportional hazard models were used to evaluate the association between frailty and gastrointestinal bleeding incidence. Results: Among the 352,060 participants (mean age 56.1 years), 3.6% ( Conclusion: Frailty significantly elevates the risk of gastrointestinal bleeding. Early identification and targeted multidimensional interventions addressing frailty may reduce gastrointestinal bleeding events and improve patient prognosis.
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