Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members.

Michael N Dretsch, Katie M Williams, Diana P Evans, Katrina S Monti, Brian J Guise, Mark L Ettenhofer, Jamie N Hershaw

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Article in Clinical neurophysiology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Michael N DretschTraumatic Brain Injury Center of Excellence (TBICoE), Silver Spring, USA.

Katie M WilliamsTraumatic Brain Injury Center of Excellence (TBICoE), Silver Spring, USA.

Diana P EvansTraumatic Brain Injury Center of Excellence (TBICoE), Silver Spring, USA.

Katrina S MontiTraumatic Brain Injury Center of Excellence (TBICoE), Silver Spring, USA.

Brian J GuiseWalter Reed National Military Medical Center, Bethesda, MD, USA.

Mark L EttenhoferTraumatic Brain Injury Center of Excellence (TBICoE), Silver Spring, USA.

Jamie N HershawTraumatic Brain Injury Center of Excellence (TBICoE), Silver Spring, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to assess the contribution of demographics, medical history, and psychological health to pupillary light reflex (PLR) indices in Service members with and without a history of mild traumatic brain injury (mTBI). Methods: PLR data from NeurOptics NPi-300 were analyzed on 216 participants who were categorized as non-injured controls (NIC), mTBI with no loss of consciousness (mTBI Results: There were no significant group differences on the PLR indices. Age was a significant factor across groups, but more robust for those with mTBI. Sleep duration, injury characteristics, and psychological health effects on PLR indices were primarily observed in the mTBI Conclusions: When using PLR for screening of mTBI, an individual's age, history of prior mTBI, total lifetime TBI-related alterations in consciousness, sleep, and anxiety and depression symptoms should be considered when interpreting PLR metrics. Significance: Controlling for these factors is essential for validating the use of PLR for screening of mTBI.

Indexed as

Brain injury characteristicsMild traumatic brain injuryPsychological healthPupillary light reflex

Identifiers

PMID40687076

DOI10.1016/j.cnp.2025.07.002

PMCPMC12274732

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.