ArticleFrontiers in medical technology2025
Sustained acoustic medicine increases local circulation with a diclofenac delivery patch: a randomized placebo controlled study.
Article in Frontiers in medical technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06510062 (Comparative Evaluation of Sustained Acoustic Medicine Device on Circulation), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Evaluation of Sustained Acoustic Medicine Device on Circulation
Who cites it
1 citing paper in PubMed.
- Long Duration Ultrasound: Recent Advancements and Clinical Applications.International journal on physical medication & rehabilitation · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sustained Acoustic Medicine (SAM) is a non-invasive long-term wearable device that delivers localized long duration high-frequency continuous ultrasound. SAM's biomechanical and diathermic stimuli enhance local circulation and oxygenation, accelerate tissue healing, and alleviate pain. The sonophoresis effects of SAM further improve transdermal drug delivery. Diclofenac is a topical Nonsteroidal anti-inflammatory drug for treating localized musculoskeletal (MSK) pain. Its efficacy is significantly dependent on skin porosity. This study aims to determine the diathermic effects of SAM and diclofenac on localized blood circulation. Methods: Sixty-four healthy participants were randomly assigned to four groups (Active SAM group: Results: SAM increased blood flow significantly over 60 min by 19.2 PU ( Conclusion: SAM treatment significantly increases local blood circulation after 10 min, increases temperature after 20 min, and sustains the effects of SAM's stimulation. The 2.5% diclofenac gel does not affect SAM's biological effects to increase local circulation. The study concludes that the application of diclofenac does not affect the diathermic properties of SAM exposure while enhancing the efficacy of diclofenac delivery through sonophoresis. Clinical Trial Registration: identifier NCT06510062.
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