ArticleCase reports in pediatrics2025
Accidental Methadone Toxicity in a 3-Year-Old Leading to Severe Cerebellitis and Death: A Case Report.
Article in Case reports in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Methadone is a synthetic opioid used to treat pain and opioid dependence. Despite its benefits, accidental ingestion of methadone in pediatric patients can lead to significant morbidity and mortality. Documented findings of acute toxicity secondary to methadone ingestion in children include leukoencephalopathy and cerebellitis. There is limited research into treatment and factors influencing clinical outcomes following methadone overdose in children. We report a 3-year-old child with severe brain injury and death following accidental ingestion of methadone. Our case is unique in that we were able to acquire a serum methadone level following ingestion, which was used to guide intervention and treatments. Using this case, we aim to contribute to the growing understanding of methadone toxicity while also advocating for the implementation of policies that protect our pediatric population.
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