Evidence map›Paper›PMID 40686861›Full record

ArticleFood chemistry: X2025

Identification of glycosylated flavonoids as new physiological ligands of the hazel allergen Cor a 1: Complex structures reveal different binding orientation and specificity of mono- and disaccharide derivatives.

Julian M Hendrich, Hatice Kara, Kristian Schweimer, Thessa P Jacob, Maike Schneider, Susanne Baldermann, Birgitta M Wöhrl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julian M HendrichBiochemistry IV - Biophysical Chemistry, University of Bayreuth, Universitätsstr. 30, D-95447 Bayreuth, Germany.
Hatice KaraBiochemistry IV - Biophysical Chemistry, University of Bayreuth, Universitätsstr. 30, D-95447 Bayreuth, Germany.
Kristian SchweimerBiochemistry IV - Biophysical Chemistry, University of Bayreuth, Universitätsstr. 30, D-95447 Bayreuth, Germany.
Thessa P JacobBiochemistry IV - Biophysical Chemistry, University of Bayreuth, Universitätsstr. 30, D-95447 Bayreuth, Germany.
Maike SchneiderBiochemistry IV - Biophysical Chemistry, University of Bayreuth, Universitätsstr. 30, D-95447 Bayreuth, Germany.
Susanne BaldermannFaculty of Life Science: Food, Nutrition and Health, Food Metabolome, University of Bayreuth, Fritz-Hornschuch-Str. 9, D-95326 Kulmbach, Germany.
Birgitta M WöhrlBiochemistry IV - Biophysical Chemistry, University of Bayreuth, Universitätsstr. 30, D-95447 Bayreuth, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global production of hazelnuts is rising, but hazelnut allergies remain common and severe. The PR-10-like allergen Cor a 1, found in hazel pollen and nuts, consists of different isoallergens with over 67 % sequence identity. Cor a 1 binds plant secondary metabolites like the diglycosylated flavonoid Q3O-(Glc)-Gal. Understanding the ligand binding of Cor a 1 isoallergens is crucial to understand their physiological and allergenic properties. We identified physiological mono- and diglycosylated flavonoids from hazel pollen by UHPLC/QTOF-MS and NMR spectroscopy and investigated their binding to Cor a 1 isoallergens by NMR HSQC experiments and ITC titrations. Screening analyses revealed different binding properties of isoallergens. Whereas the isoallergen Cor a 1.0501 bound only monoglycosylated flavonoids, Cor a 1.0401 also bound diglycosylated flavonoids. Protein/ligand complex structures based on NMR NOESY and computational docking experiments revealed different orientations of mono- vs. diglycosylated flavonoids in the amphiphilic pocket and specific binding of disaccharide derivatives.

Indexed as

Cor a 1 isoallergensDockingGlycosylated flavonoidsHSQCITCNOESYPR-10 proteinsUHPLC/QTOF-MS/MS

Identifiers

PMID40686861
PMCPMC12275138

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.