Evidence map›Paper›PMID 40686851›Full record

ArticleExploratory research in clinical and social pharmacy2025

Not so great expectations: The role of price and name information in the nocebo effect.

Kiarne Humphreys, Michelle Lin, Kirsten Barnes, Yasmin Hasan, Ashwin Vignaraja, Kritika Sarna, Andrew L Geers, Kate Faasse

Abstract read
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In one paragraph

Article in Exploratory research in clinical and social pharmacy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kiarne HumphreysSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Michelle LinSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Kirsten BarnesSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Yasmin HasanSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Ashwin VignarajaSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Kritika SarnaSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Andrew L GeersDepartment of Psychology, University of Toledo, Toledo, OH, USA.
Kate FaasseSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The perception of taking a generic medication can result in reduced efficacy and increased side effects, despite equivalence to brand name medications under double blind conditions. It may be that cues typically associated with generics, including lower price and more complex name, exacerbate negative expectations and cause nocebo effects. Methods: Healthy participants ( Results: Nocebo effects were observed across sham-treated participants relative to control ( Conclusions: Cues associated with generic medications can exacerbate nocebo effects and these findings may explain clinical observations of increased side effects from generic medications. Results have important implications for medical care, and interventions to mitigate nocebo effects from generic medications are needed.

Indexed as

Drug namesExpectationsGeneric medicationNocebo effectPriceSide effects

Identifiers

PMID40686851
PMCPMC12274324

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.