Evidence map›Paper›PMID 40686821›Full record

ArticleFrontiers in nutrition2025

A novel malnutrition assessment model predicts the inflammatory storm of relapsed/refractory acute myeloid leukemia following C-type lectin-like molecule-1 chimeric antigen receptor T therapy.

Tao Zhang, Mengnan Li, Xiaomei Zhang, Mohan Zhao, Yanyu Jiang, Xin Wang, Yifan Zhao, Xiaoxue Shi, Wentao Qu, Yu Zhang and 3 more

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Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tao ZhangNankai University, Tianjin, China.
Mengnan LiNankai University, Tianjin, China.
Xiaomei ZhangNankai University, Tianjin, China.
Mohan ZhaoThe First Central Clinical College of Tianjin Medical University, Tianjin, China.
Yanyu JiangDepartment of Hematology, School of Medicine, Tianjin First Central Hospital, Tianjin Thrombosis and Hemostasis Institute, Nankai University, Tianjin, China.
Xin WangThe First Central Clinical College of Tianjin Medical University, Tianjin, China.
Yifan ZhaoThe First Central Clinical College of Tianjin Medical University, Tianjin, China.
Xiaoxue ShiThe First Central Clinical College of Tianjin Medical University, Tianjin, China.
Wentao QuThe First Central Clinical College of Tianjin Medical University, Tianjin, China.
Yu ZhangDepartment of Hematology, School of Medicine, Tianjin First Central Hospital, Tianjin Thrombosis and Hemostasis Institute, Nankai University, Tianjin, China.
Xue BaiDepartment of Hematology, School of Medicine, Tianjin First Central Hospital, Tianjin Thrombosis and Hemostasis Institute, Nankai University, Tianjin, China.
Bing WangDepartment of Hematology, School of Medicine, Tianjin First Central Hospital, Tianjin Thrombosis and Hemostasis Institute, Nankai University, Tianjin, China.
Mingfeng ZhaoDepartment of Hematology, School of Medicine, Tianjin First Central Hospital, Tianjin Thrombosis and Hemostasis Institute, Nankai University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Previous studies have been insufficient in addressing malnutrition in leukemia patients and inflammatory storms following immunotherapy infusion. This study investigates the relationship between malnutrition and inflammatory storm after C-type lectin-like molecule-1 chimeric antigen receptor T (CLL1 CAR-T) infusion in relapsed/refractory acute myeloid leukemia (r/r AML) patients. Methods: In this single-center study, we adopted Controlling Nutritional Status (CONUT) and modified Controlling Nutritional Status (mCONUT) to assess the patient's malnutrition status. The score of CONUT/mCONUT and the severity and grading of cytokine storm at different time points were collected. The area under the receiver operating curve (AUC) was used to evaluate the malnutrition score to predict the early inflammatory storm after CLL1 CAR-T infusion. Results: Higher malnutrition scores were significantly associated with increased severity of cytokine release storm (CRS). On Day + 7 and Day + 14 after CLL1 CAR-T infusion, the prediction efficiency of the malnutrition assessment model was high, AUC was greater than 0.8, and CONUT Day + 7 reached the peak (AUC = 0.813), and CONUT Day + 14 (AUC = 0.8009). mCONUT Day + 7 reached the peak (AUC = 0.821), and mCONUT Day + 14 (AUC = 0.8162). Conclusion: Early malnutrition assessment models are practical, objective tools for predicting inflammatory storms in relapsed/refractory AML patients undergoing CLL1 CAR-T therapy.

Indexed as

chimeric antigen receptor T (CAR-T)cytokine release storm (CRS)inflammationleukeamiamalnutrition

Identifiers

PMID40686821
PMCPMC12270871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.