ArticleFrontiers in nutrition2025
Association between albumin-bilirubin score and sarcopenia in middle-aged Americans: a cross-sectional study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Assessing the hepatic and renal parameters of breast cancer patient blood samples before and after chemotherapy.Toxicology reports · 2026Article
- Association between the albumin-bilirubin score and gallstone prevalence: evidence from NHANES and an independent hospital-based cohort.Frontiers in medicine · 2026Article
- Risk prediction of sarcopenia in a large health checkup population: development and validation of a dynamic online nomogram.Frontiers in public health · 2026Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The albumin-bilirubin (ALBI) score is a novel index for assessing liver function, integrating albumin and bilirubin levels to provide a comprehensive evaluation of a patient's overall health. Despite its utility, there is a paucity of research exploring the relationship between ALBI scores and sarcopenia in the existing literature, and studies on sarcopenia prevalence in middle-aged adults are also scarce. This study aims to investigate the association between ALBI scores and the prevalence of sarcopenia among middle-aged adults in the United States. Methods: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected from 2011 to 2018, participants were classified into prevalent and non-prevalent groups based on sarcopenia status. We constructed one univariate model and two multivariate models, employing restricted cubic spline analysis and weighted logistic regression to examine the relationship between ALBI scores and sarcopenia prevalence. Additionally, subgroup analyses assessed the association between ALBI scores and sarcopenia across various demographic groups. A random forest model was also developed to evaluate the importance of different variables related to sarcopenia, based on Gini impurity. Results: The study included a total of 10,354 participants. Analysis of demographic characteristics stratified by sarcopenia prevalence. In the fully adjusted model, a positive association was found between ALBI scores and sarcopenia prevalence [OR (95% CI): 4.28 (2.29, 8.01), Conclusion: This study establishes a significant association between ALBI scores and sarcopenia prevalence in middle-aged adults in the United States. Our findings indicate that higher ALBI scores are correlated with an increased prevalence of sarcopenia, emphasizing the importance of incorporating ALBI scores into assessments of muscle health. These results suggest that ALBI scores could play a crucial role in informing preventive strategies and interventions to combat sarcopenia in this vulnerable population.
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