Evidence map›Paper›PMID 40686812›Full record

ArticleFrontiers in nutrition2025

Lifestyle can exert a significant impact on the development of metabolic comorbidities in early-stage colorectal cancer patients.

Yu Xin, Chunxia Liu, Jianfang Cui, Yanan Wang, Honglei Wu

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu XinDepartment of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Chunxia LiuDepartment of Gastroenterology, People's Hospital of Xiajin County, Dezhou, Shandong, China.
Jianfang CuiDepartment of Gastroenterology, Beijing Shijitan Hospital, Beijing, China.
Yanan WangDepartment of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Honglei WuDepartment of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Metabolic dysregulation has been identified as contributing to colorectal cancer (CRC) development. However, there is a lack of data regarding the association between lifestyle factors and metabolic diseases in CRC patients. Methods: We conducted a multi-center cross-sectional study including 437 early-stage CRC patients and 437 control participants between April 2023 and March 2024. The dietary inflammatory index (DII) was calculated based on dietary data, which was collected using a food frequency questionnaire. A healthy lifestyle was defined as adherence to an anti-inflammatory diet (DII score < 0) combined with active physical activity. Results: Among early-stage CRC patients, overweight and obesity were associated with an anti-inflammatory diet (OR = 0.585, 95% CI = 0.346-0.988, Conclusion: Adherence to healthy lifestyles, particularly in individuals aged ≥50 years, may alleviate metabolic dysregulation in early-stage CRC patients.

Indexed as

early-stage colorectal cancerlifestylemetabolic dysfunction-associated fatty liver diseasemetabolic syndrometype 2 diabetes mellitus

Identifiers

PMID40686812
PMCPMC12272228

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.