Evidence map›Paper›PMID 40686795›Full record

ArticleRadiology case reports2025

Severe dengue encephalitis showcasing the "double doughnut sign" on MRI: A case report.

Salhadin Mohammed, Aman Edao Bime, China Tolessa Sedi, Hussen Nuri Saliha, Surafel Tilahun Maru, Abdulfatah Workicho Mustafa

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Salhadin MohammedInternal Medicine Department, Division of Neurology, School of Medicine, College of Health Sciences, Wollo University, Dessie, Ethiopia.
Aman Edao BimeAnaesthesiology, Critical Care, and Pain Medicine Department, School of Medicine, College of Health Sciences, Haramaya University, Harar, Ethiopia.
China Tolessa SediNeurosurgery Department, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Hussen Nuri SalihaNeurology Department, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Surafel Tilahun MaruNeurology Department, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Abdulfatah Workicho MustafaRadiology Department, School of Medicine, College of Health Sciences, University of Gondar Comprehensive Specialized Hospital, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe dengue can lead to fatal complications, including dengue encephalitis. We report a 14-year-old girl with severe dengue who presented with bilateral thalamic hemorrhagic infarction, indicated by distinct brain imaging findings (the so-called "double doughnut sign"), which is a rare presentation of a common infection. Positive dengue antigen and IgM tests were noted. The patient required critical care, including intubation and resuscitation, but was discharged improved and continues follow-up at our neurology clinic. This case highlights that dengue infection can be complicated by meningoencephalitis, and a high index of suspicion is needed to diagnose our patients promptly. Furthermore, imaging modalities such as MRI play a key role in diagnosing and managing patients with dengue encephalitis.

Indexed as

Case reportDengue encephalitisDouble doughnut signMRISevere dengue

Identifiers

PMID40686795
PMCPMC12272762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.