Evidence map›Paper›PMID 40686779›Full record

ReviewNeurobiology of pain (Cambridge, Mass.)

Neuronal physiology of amygdala neurons in the context of injury and pain.

Blesson K Paul, Maria Isabel Nunez-Ordaz, Joseph R Samuel, Benedict J Kolber

Abstract readReview
In one paragraph

Review in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Blesson K PaulDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, United States.
Maria Isabel Nunez-OrdazDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, United States.
Joseph R SamuelDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, United States.
Benedict J KolberDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, United States.

Funding

Impact of Amygdala Lateralization on Processing and Modulation of Bladder PainR01DK115478 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI BENEDICT J KOLBER · 2018 to 2026
$4.3M
NIDDK NIH HHS R01 DK115478
6 · The paper itself

Abstract

The amygdala integrates polymodal information including nociceptive stimuli. It is implicated as a key node in regulating both sensory-discriminative and emotional-affective aspects of pain and central sensitization. While central sensitization mechanisms in persistent pain are not completely understood, studying the neuronal properties exhibited by the amygdala neurons within their functional context, in this case, nociception, is important. Such studies can shed light on the behavior-modulating potential of the amygdala. In the last twenty years, multiple laboratories have begun the process of dissecting the cell-type specific activity involved in amygdala function. This review surveys these electrophysiological properties of neurons from different amygdala nuclei, cell types and circuitry studied so far, in the context of nociception and injury. A population-level accounting of these cell types provides greater insight into identifying specific targets to develop interventions for pain-mediated affective conditions.

Indexed as

AmygdalaBasolateral AmygdalaCalcitonin Gene Related Peptide ReceptorCentral AmygdalaCognitive-ImpairmentCorticotrophin Releasing FactorElectrophysiologyLateralizationNeuronal PhysiologyNociceptionOpioid receptorsPainPain-mediated membrane excitabilityPain-mediated synaptic plasticityParabrachial NucleusPrefrontal CortexProtein Kinase C δSomatostatinSynaptic Plasticity

Identifiers

PMID40686779
PMCPMC12272620

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.