Evidence map›Paper›PMID 40686634›Full record

ArticleRSC advances2025

Inhibitory mechanism of pterostilbene and pinostilbene on aldose reductase and α-glucosidase: a new insight from inhibition kinetics and molecular docking studies.

Lili Jiang, Yanyan Jia, Hang Yin, Yong Liu

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lili JiangSchool of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology No. 2 Dagong Road, Liaodongwan New District Panjin 124221 Liaoning China yliu@dlut.edu.cn +86-04272631433.
Yanyan JiaSchool of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology No. 2 Dagong Road, Liaodongwan New District Panjin 124221 Liaoning China yliu@dlut.edu.cn +86-04272631433.
Hang YinSchool of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology No. 2 Dagong Road, Liaodongwan New District Panjin 124221 Liaoning China yliu@dlut.edu.cn +86-04272631433.
Yong LiuSchool of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology No. 2 Dagong Road, Liaodongwan New District Panjin 124221 Liaoning China yliu@dlut.edu.cn +86-04272631433.ORCID https://orcid.org/0000-0002-6173-8186

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pterostilbene, a dietary polyphenol in blueberries, grapes and wine, possesses an anti-diabetic efficacy. However, the mechanism of anti-diabetic efficacy for pterostilbene is poorly understood. The purpose of the present study was to systematically investigate inhibitory effects and inhibition mechanisms of pterostilbene or its metabolite (pinostilbene) against aldose reductase and α-glucosidase. In the present study, inhibition kinetics and molecular docking were applied to investigate the effect of pterostilbene and pinostilbene on the activity of aldose reductase and α-glucosidase. The results showed that pinostilbene exhibited stronger inhibition on aldose reductase (IC

Identifiers

PMID40686634
PMCPMC12272566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.