ArticleiScience2025
Analysis of clinical characteristics and factors of central nervous system damage caused by acute bipyridine herbicide poisoning.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Analysis on quality of life, anxiety, and depression of diquat self-poisoning after returning to the community: a follow-up study.Frontiers in public health · 2026Article
- Molecular mechanisms in diquat-induced organs injury：insights into cell signaling and potential therapeutic agents.Cell biology and toxicology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute bipyridine herbicide poisoning poses a significant clinical challenge due to the lack of an effective antidote, with CNS damage leading to particularly poor outcomes. This retrospective study included 189 patients with acute bipyridine poisoning, with a median age of 39 years. Among them, 33.3% developed CNS damage, with a median onset time of 48 h, and overall mortality was 50.8%. Correlation analyses revealed that both diquat (DQ) and paraquat (PQ) poisoning were associated with systemic damage. However, DQ poisoning showed additional associations with inflammatory markers (WBC [white blood cell], neutrophils), liver dysfunction (alanine aminotransferase [ALT]), and CNS damage, underscoring its broader systemic impact. To address the need for early identification of CNS damage, we developed a robust 8-factor predictive model. Its performance, validated through receiver operating characteristic (ROC) curve analysis, calibration curves, and decision curve analysis (DCA), demonstrated strong clinical potential for improving early risk stratification and guiding targeted interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.