Evidence map›Paper›PMID 40686616›Full record

ArticleiScience2025

Estrogen-mediated corneal collagen degradation in keratoconus.

Amit Chatterjee, Levi N Kanu, Nikolay Boychev, Amy E Ross, Vincent Yeung, Nandini Venkateswaran, Hajirah N Saeed, Joseph B Ciolino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amit ChatterjeeDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Levi N KanuDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Nikolay BoychevDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Amy E RossDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Vincent YeungDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Nandini VenkateswaranDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Hajirah N SaeedDepartment of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL, USA.
Joseph B CiolinoDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.

Funding

CORNEAL STROMAL-EPITHELIAL INTERACTIONS DURING REPAIRR01EY005665 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Joseph B. Ciolino · 1985 to 2026
$14.4M
Mass Eye and Ear-Vision Clinical Scientist Development ProgramK12EY016335 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Reza Dana · 2004 to 2026
$12.3M
NEI NIH HHS K12 EY016335NEI NIH HHS R01 EY005665
6 · The paper itself

Abstract

Keratoconus (KC) is characterized by corneal thinning due to pathologic degradation of corneal stromal collagen. This study investigates the role of β-estradiol in corneal collagen degradation using both tear fluid samples from KC and non-KC patients and

Indexed as

BiochemistryCell biology

Identifiers

PMID40686616
PMCPMC12274804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.