ArticleAnnals of neurosciences2025
Microglial Dystrophy and Spatial Learning Impairments Following Exposure to Multiple Early-life Stressors in Rats.
Article in Annals of neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adversities during perinatal critical windows act as a major risk factor for several psychopathologies during adolescence and adulthood. Protein malnutrition, infections, neurotoxicant exposure and social stressors are significant adverse factors encountered by neonates born to socio-economically compromised societies. Purpose: The purpose of this study is to understand how the cumulative exposure to multiple perinatal stressors can result in conditions that mimic various neurological disorders in affected individuals later in life. The present study aimed to understand the involvement of microglia, their activation, priming and dystrophy due to multi-hit exposure in severe spatial learning and memory impairments. Methods: Naïve female Wistar rats ( Results: Results revealed that LP F1-treated rats were more susceptible to stressors with reduced brain weight, long-term microglial activation specifying primed states with enhanced expression of CD11b/CR3, MHC-II/OX-6 and ED2. Conclusion: Multi-hit exposure induced dystrophic changes in a large population of microglia, causing severe learning and memory impairments, suggesting that perinatal multi-hit exposure might become a significant risk factor for developmental disorders in adulthood.
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