ReviewJournal of molecular and cellular cardiology plus2025
Cardiology's best friend: Using naturally occurring disease in dogs to understand heart disease in humans.
Review in Journal of molecular and cellular cardiology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- One Health Insights into Pulmonary Hypertension: Bridging Human and Canine Medicine.Veterinary sciences · 2026Review
- From bench to bedside and back: translational cardiovascular interventions in veterinary medicine.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart diseases are a leading cause of death globally. Laboratory and preclinical animal models of disease have been critical in advancing our understanding of the mechanisms of pathology, creating diagnostic tools, and developing therapeutic interventions. However, fundamental biological dissimilarities between humans and rodents limits their usefulness in research, and the induction of disease in an otherwise healthy animal creates unrealistic conditions under which diseases are typically studied. Dogs are at high risk of acquiring and dying from several naturally occurring heart disorders that also affect people. The spontaneous nature of these conditions, along with highly similar cardiovascular systems, offers unique opportunities to investigate cardiovascular disease in a more relevant model for humans. This review focuses on three common cardiac conditions that impact humans and dogs: dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and mitral valve disease - comparing mechanisms of disease, diagnostics, and treatments, to identify strengths and present limitations of their utility. It is noted that the benefits of this research are bidirectional, with the potential to translate knowledge and clinical tools used in veterinary medicine to human patients, and vice versa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.