Evidence map›Paper›PMID 40686479›Full record

ArticleBiomaterials science2025

Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance.

Peng Chen, Shaphan Jernigan, Keren Zhao, George Varghese P J, Mitesha Saha, Charles Kim, Amirhossein Arzani, Gregory Buckner, Jingjie Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng ChenDepartment of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.ORCID http://orcid.org/0000-0003-3234-4193
Shaphan JerniganDepartment of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.
Keren ZhaoDepartment of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.
George Varghese P JDepartment of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.
Mitesha SahaDepartment of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.
Charles KimDivision of Vascular and Interventional Radiology, Department of Radiology, Duke University Medical Center, Durham, NC, USA.
Amirhossein ArzaniDepartment of Mechanical Engineering, University of Utah, Salt Lake City, UT, USA.
Gregory BucknerDepartment of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.
Jingjie HuDepartment of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.ORCID http://orcid.org/0000-0002-3052-9496

Funding

Integrated experimental and computational approach for accurate patient-specific vascular embolizationR21AG083692 · NIA · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ARZANI, AMIRHOSSEIN, HU, JINGJIE · 2023 to 2025
$581k
Developing Therapeutic Gel Embolic Agents for Arteriovenous Malformation EmbolizationR03EB033633 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HU, JINGJIE · 2023 to 2024
$144k
NIA NIH HHS R21 AG083692NIBIB NIH HHS R03 EB033633
6 · The paper itself

Abstract

Transcatheter arterial embolization (TAE) is a minimally invasive technique used to treat hypervascular tumors, hemorrhage, and vascular abnormalities. Though microspheres (MSs) have achieved widespread clinical use as embolic agents, they often lack imaging opacity, optimal morphology and mechanical properties which can lead to unpredictable trajectories, non-target delivery, and suboptimal embolization. This study developed tantalum-loaded calcium alginate (Ta@Ca-Alg) MSs with intrinsic radiopacity, tunable density, and mechanical properties. Ta@Ca-Alg MSs were synthesized using a gas-shearing method and analyzed for size, morphology, swelling behavior, density, radiopacity, and optimized mechanical properties. The results demonstrated that Ta@Ca-Alg MSs maintained a narrow size distribution, with increasing Ta concentration enhancing radiopacity to levels comparable with the clinical contrast agent OMNIPAQUE 350. Density and Young's modulus corresponding to different Ta concentrations were also investigated. Phantom model testing validated effective vessel occlusion and controlled penetration.

Indexed as

AlginatesEmbolization, TherapeuticMicrospheresTantalumAnimalsCell SurvivalContrast MediaHumansMicePhantoms, ImagingAlginatesContrast MediaTantalum

Identifiers

PMID40686479
PMCPMC13439238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.